“Double-Twist”-Based Dynamic Induction of Optical Activity in Multichromophoric System

The electronic circular dichroism (CD)-silent 2,5-bis(biphen-2-yl)terephthalaldehyde has been used as a sensor (reporter) of chirality for primary amines. through-space inductor–reporter interactions force change in the chromophore conformation toward one diastereomeric forms. structure reporter, with terminal flipping biphenyl groups, led to generating Cotton effects both lower- and higher-energy regions ECD spectrum. induction an optical activity was due cascade point-to-axial transmission mechanism. reporter system turned out be sensitive subtle differences inductor structure. Despite size chiral substituent, molecular systems solid-state showed many similarities. most important tendency core part molecules adapt pseudocentrosymmetric conformation. Supported by weak dispersion Van der Waals interactions, face-to-face edge-to-face between ?-electron present molecule were found responsible arrangement crystal.